Note: This document contains side effect information about sertraline. Some of the dosage forms listed on this page may not apply to the brand name Zoloft. Zoloft is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Antidepressant Warnings: There have been 151 warnings from 11 countries (Australia, Canada, Denmark, Germany, Ireland, Italy, Japan, New Zealand, Russia, United Kingdom and United States) and the European Union warning that antidepressants cause harmful side effects. Find information about common, infrequent and rare side effects of Zoloft Oral. Pictures of Zoloft (Sertraline Hcl), drug imprint information, side effects for the patient. Drug Information on Zoloft (sertraline) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. Zoloft is a super-common antidepressant and anti-anxiety medication, but there are some side effects you should be aware of. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Zoloft is an SSRI (selective serotonin reuptake inhibitors) antidepressant prescribed for the treatment of depression, obsessive compulsive disorder , panic disorder, posttraumatic stress disorder , social anxiety disorder, and premenstrual dysphoric disorder. Zoloft is available as a generic drug. Zoloft (sertraline) is an antidepressant used to treat depression and anxiety. While generally safe, there are some side effects you should watch out for.